stoppingrule: Create and Evaluate Stopping Rules for Safety Monitoring

Provides functions for creating, displaying, and evaluating stopping rules for safety monitoring in clinical studies. Implements stopping rule methods described in Goldman (1987) <doi:10.1016/0197-2456(87)90153-X>; Geller et al. (2003, ISBN:9781135524388); Ivanova, Qaqish, and Schell (2005) <doi:10.1111/j.1541-0420.2005.00311.x>; Chen and Chaloner (2006) <doi:10.1002/sim.2429>; and Kulldorff et al. (2011) <doi:10.1080/07474946.2011.539924>.

Version: 0.4.0
Imports: stats, utils, graphics, pracma, matrixStats
Published: 2024-03-17
DOI: 10.32614/CRAN.package.stoppingrule
Author: Michael J. Martens [aut,cre], Qinghua Lian [aut], Brent R. Logan [ctb]
Maintainer: Michael J. Martens <mmartens at>
License: GPL-3
NeedsCompilation: no
Materials: README
CRAN checks: stoppingrule results


Reference manual: stoppingrule.pdf


Package source: stoppingrule_0.4.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): stoppingrule_0.4.0.tgz, r-oldrel (arm64): stoppingrule_0.4.0.tgz, r-release (x86_64): stoppingrule_0.4.0.tgz, r-oldrel (x86_64): stoppingrule_0.4.0.tgz
Old sources: stoppingrule archive


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