RARfreq: Response Adaptive Randomization with 'Frequentist' Approaches

Provides functions and command-line user interface to generate allocation sequence by response-adaptive randomization for clinical trials. The package currently supports two families of frequentist response-adaptive randomization procedures, Doubly Adaptive Biased Coin Design ('DBCD') and Sequential Estimation-adjusted Urn Model ('SEU'), for binary and normal endpoints. One-sided proportion (or mean) difference and Chi-square (or 'ANOVA') hypothesis testing methods are also available in the package to facilitate the inference for treatment effect. Additionally, the package provides comprehensive and efficient tools to allow one to evaluate and compare the performance of randomization procedures and tests based on various criteria. For example, plots for relationship among assumed treatment effects, sample size, and power are provided. Five allocation functions for 'DBCD' and six addition rule functions for 'SEU' are implemented to target allocations such as 'Neyman', 'Rosenberger' Rosenberger et al. (2001) <doi:10.1111/j.0006-341X.2001.00909.x> and 'Urn' allocations.

Version: 0.1.5
Imports: dplyr, ggplot2, latex2exp, magrittr, patchwork, stats, tidyr, data.table, reshape2, Rdpack
Suggests: spelling, testthat (≥ 3.0.0)
Published: 2024-05-07
DOI: 10.32614/CRAN.package.RARfreq
Author: Mengjia Yu [aut], Xiu Huang [aut, cre], Li Wang [aut], Hongjian Zhu [aut]
Maintainer: Xiu Huang <xiu.huang at aya.yale.edu>
License: MIT + file LICENSE
NeedsCompilation: no
Language: en-US
Materials: README
CRAN checks: RARfreq results


Reference manual: RARfreq.pdf


Package source: RARfreq_0.1.5.tar.gz
Windows binaries: r-devel: RARfreq_0.1.5.zip, r-release: RARfreq_0.1.5.zip, r-oldrel: RARfreq_0.1.5.zip
macOS binaries: r-release (arm64): RARfreq_0.1.5.tgz, r-oldrel (arm64): RARfreq_0.1.5.tgz, r-release (x86_64): RARfreq_0.1.5.tgz, r-oldrel (x86_64): RARfreq_0.1.5.tgz
Old sources: RARfreq archive


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