OneArm2stage: Phase II Single-Arm Two-Stage Designs with Time-to-Event Outcomes

Two-stage design for single-arm phase II trials with time-to-event endpoints (e.g., clinical trials on immunotherapies among cancer patients) can be calculated using this package. Two notable advantages of the package: 1) It provides flexible choices from three design methods (optimal, minmax, and admissible), and 2) the power of the design is more accurately calculated using the exact variance in the one-sample log-rank test. The package can be used for 1) planning the sample sizes and other design parameters, and 2) conducting the interim and final analyses for the Go/No-go decisions. More details about the design method can be found in: Wu, J, Chen L, Wei J, Weiss H, Chauhan A. (2020). <doi:10.1002/pst.1983>.

Version: 1.2.1
Depends: R (≥ 3.5.0)
Imports: survival, utils, flexsurv, IPDfromKM
Suggests: knitr, rmarkdown, testthat (≥ 3.0.0)
Published: 2023-10-09
DOI: 10.32614/CRAN.package.OneArm2stage
Author: Xiaomeng Yuan [aut, cre], Haitao Pan [aut], Jianrong Wu [aut]
Maintainer: Xiaomeng Yuan <xiaomeng.yuan at>
License: GPL (≥ 3)
NeedsCompilation: no
Materials: NEWS
CRAN checks: OneArm2stage results


Reference manual: OneArm2stage.pdf
Vignettes: OneArm2stage


Package source: OneArm2stage_1.2.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): OneArm2stage_1.2.1.tgz, r-oldrel (arm64): OneArm2stage_1.2.1.tgz, r-release (x86_64): OneArm2stage_1.2.1.tgz, r-oldrel (x86_64): OneArm2stage_1.2.1.tgz
Old sources: OneArm2stage archive


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